Different effect of sodium butyrate on cancer and normal prostate cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33146998" target="_blank" >RIV/61989592:15110/13:33146998 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/13:#0000454
Result on the web
<a href="http://dx.doi.org/10.1016/j.tiv.2013.03.002" target="_blank" >http://dx.doi.org/10.1016/j.tiv.2013.03.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tiv.2013.03.002" target="_blank" >10.1016/j.tiv.2013.03.002</a>

Result language
angličtina
Original language name
Different effect of sodium butyrate on cancer and normal prostate cells
Original language description
Sodium butyrate, as a naturally occurring inhibitor of histone deacetylases (HDACI), is a non-toxic agent, with an ability to change histone acetylation and expression of large number genes. This study shows different effects of sodium butyrate on expression and transcription activity of the androgen receptor in cancer (LNCaP, C4-2) and normal (RWPE-1) prostate cells. Moreover, we studied the coregulator expressions and histone acetylation alteration in cancer and normal cells. Coregulators, coactivators as well as corepressors, play an important role in AR-mediated growth and progression of prostate cancer. There is a competition between coactivators and corepressors for binding on the AR and therefore the changes in coregulators expression and ratiocould be important for prostate cancer survival. Our study was focused on two coregulators, SMRT and p300, which interact with AR in multiprotein complex and affect the AR transcription activity. Our data indicate that sodium butyrate has
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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