Dosage Compensation of an Aneuploid Genome in Mouse Spermatogenic Cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33149712" target="_blank" >RIV/61989592:15110/14:33149712 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/14:00431298
Result on the web
<a href="http://dx.doi.org/10.1095/biolreprod.114.118497" target="_blank" >http://dx.doi.org/10.1095/biolreprod.114.118497</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1095/biolreprod.114.118497" target="_blank" >10.1095/biolreprod.114.118497</a>
Alternative languages
Result language
angličtina
Original language name
Dosage Compensation of an Aneuploid Genome in Mouse Spermatogenic Cells
Original language description
Autosomal trisomies and monosomies bring serious threats to embryonic development through transcriptional disarray caused primarily by the dosage effect of the aneuploid part of the genome. The present study compared the effect of a mouse-viable 30-Mb segmental trisomy on the genome-wide transcriptional profile of somatic (liver) cells and male germ cells. Although the 1.6-fold change in expression of triplicated genes reflected the gene dosage in liver cells, the extra copy genes were compensated in early pachytene spermatocytes, showing 1.18-fold increase. Although more pronounced, the dosage compensation of trisomic genes was concordant with the incidence of HORMAD2 protein and histone gammaH2AX markers of unsynapsed chromatin. A possible explanation for this includes insufficient sensitivity to detect the meiotic silencing of unsynapsed chromatin markers in the 30-Mb region of the chromosome or an earlier silencing effect of another epigenetic factor. Taken together, our results in
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BIOLOGY OF REPRODUCTION
ISSN
0006-3363
e-ISSN
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Volume of the periodical
90
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1-9
UT code for WoS article
000337674200009
EID of the result in the Scopus database
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