Macrophage Polarization and Activation in Response to Implant Debris: Influence by "Particle Disease" and "Ion Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33153041" target="_blank" >RIV/61989592:15110/14:33153041 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1615/JLongTermEffMedImplants.2014011355" target="_blank" >http://dx.doi.org/10.1615/JLongTermEffMedImplants.2014011355</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1615/JLongTermEffMedImplants.2014011355" target="_blank" >10.1615/JLongTermEffMedImplants.2014011355</a>
Alternative languages
Result language
angličtina
Original language name
Macrophage Polarization and Activation in Response to Implant Debris: Influence by "Particle Disease" and "Ion Disease
Original language description
Macrophages derive from human embryonic and fetal stem cells and from human bone marrow-derived blood monocytes. They play a major homeostatic role in tissue remodeling and maintenance facilitated by apoptotic "eat me" opsonins like CRP, serum amyloid P,C1q, C3b, IgM, ficolin, and surfactant proteins. Three subsets of monocytes, classic, intermediate, and nonclassic, are mobilized and transmigrate to tissues. Implant-derived wear particles opsonized by danger signals regulate macrophage priming, polarization (M1, M2, M17, and Mreg), and activation. CD14+ monocytes in healthy controls and CD16+ monocytes in inflammation differentiate/polarize to foreign body giant cells/osteoclasts or inflammatory dendritic cells (infDC). These danger signal opsonins can be pathogen- or microbe-associated molecular patterns (PAMPs/MAMPs), but in aseptic loosening, usually are damage-associated molecular patterns (DAMPs). Danger signal-opsonized particles elicit "particle disease" and aseptic loosening.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FI - Traumatology and orthopaedics
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Long-Term Effects of Medical Implants
ISSN
1050-6934
e-ISSN
—
Volume of the periodical
24
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
267-281
UT code for WoS article
—
EID of the result in the Scopus database
—