The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33163275" target="_blank" >RIV/61989592:15110/14:33163275 - isvavai.cz</a>
Result on the web
<a href="http://cancerci.biomedcentral.com/articles/10.1186/1475-2867-14-41" target="_blank" >http://cancerci.biomedcentral.com/articles/10.1186/1475-2867-14-41</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1475-2867-14-41" target="_blank" >10.1186/1475-2867-14-41</a>

Result language
angličtina
Original language name
The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance
Original language description
Tumors are not merely masses of neoplastic cells but complex tissues composed of cellular and noncellular elements. This review provides recent data on the main components of a dynamic systém, such as carcinoma associated fibroblasts that change the extracellular matrix topology, induce stemness and promote metastasis-initiating cells. Altered production and characteristics of collagen, hyaluronan and other ECM proteins induce increased matrix stiffness.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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