Chromosome 6q deletion correlates with poor prognosis and low relative expression of FOXO3 in chronic lymphocytic leukemia patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73581117" target="_blank" >RIV/61989592:15110/17:73581117 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/17:00067568 RIV/00669806:_____/17:10363732 RIV/00216224:14110/17:00095685 RIV/00098892:_____/17:N0000140
Result on the web
<a href="http://dx.doi.org/10.1002/ajh.24852" target="_blank" >http://dx.doi.org/10.1002/ajh.24852</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ajh.24852" target="_blank" >10.1002/ajh.24852</a>
Alternative languages
Result language
angličtina
Original language name
Chromosome 6q deletion correlates with poor prognosis and low relative expression of FOXO3 in chronic lymphocytic leukemia patients
Original language description
Detection of genetic changes has improved the current risk stratifica-tion in chronic lymphocytic leukemia (CLL).1,2Among the known recur-rent chromosomal abnormalities,16q deletion is less frequent andcontroversy surrounding its prognostic significance still remains.3,4The study aimed at a genetic analysis of a group of CLL patientswith chromosome 6q deletion for determination of its prognostic sig-nificance, extent, the minimal deleted region (MDR) using array com-parative genomic hybridization (arrayCGH), and finally to dermine therelative expression of candidate genes located therein.Peripheral blood and/or bone marrow samples from 1158 CLLpatients diagnosed and treated in three Czech hematology centers(Brno, Olomouc and Pilsen) were examined in 2001–2016 usingconventional cytogenetics (CG) and FISH. The patient characteristicsare listed in Supporting Information Table S1. Chromosome 6q dele-tion was found by CG (53) and FISH (38) in a total of 91 (7.9%)patients. Complete data and material for further analysis were avail-able for only 70 patients, including 42 patients examined at CLLdiagnosis and 28 treated patients examined in the course of the dis-ease (Table 1).Deletion 6q was confirmed as a single aberration in 10 patients,together with one additional aberration in 21 and as part of a complexkaryotype in 39 patients. Evaluation of the frequency of other changesusing a FISH CLL panel1showed that 13q deletion was the most fre-quent change regardless of the number of changes, occurring in 30/70(42.8%) patients. TP53 deletion was present in 17 (24.3%) patients,with 13 of them having a complex karyotype. The results concerningthe presence of additional changes identified by CG and FISH areshown in Supporting Information Figure S1
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Hematology
ISSN
0361-8609
e-ISSN
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Volume of the periodical
92
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
"E604"-"E607"
UT code for WoS article
000409203200010
EID of the result in the Scopus database
2-s2.0-85026459512