Regioselective synthesis of 5-[(2,3-dihydroxypropoxy)methyl]uracil analogues

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73583789" target="_blank" >RIV/61989592:15110/17:73583789 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/17:73583789
Result on the web
<a href="http://pubs.rsc.org/en/content/articlehtml/2017/nj/c7nj03019c" target="_blank" >http://pubs.rsc.org/en/content/articlehtml/2017/nj/c7nj03019c</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c7nj03019c" target="_blank" >10.1039/c7nj03019c</a>

Result language
angličtina
Original language name
Regioselective synthesis of 5-[(2,3-dihydroxypropoxy)methyl]uracil analogues
Original language description
Herein, we report the regioselective synthesis of 5-[(2,3-dihydroxypropoxy)methyl]uracil analogues with hydroxy alkyl chains that mimic the natural C-nucleoside pseudouridine. We developed multiple disparate synthetic procedures and approaches for the preparation of a wide range of derivatives, such as amino, acyl, halogen or azido compounds. Their synthesis was based on the different reactivity of primary and secondary hydroxy groups. The final compounds might be further considered as new building blocks for oligonucleotide synthesis.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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