Click Reactions in Chemistry of Triterpenes – Advances Towards Development of Potential Therapeutics

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73591031" target="_blank" >RIV/61989592:15110/18:73591031 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/18:73591031
Result on the web
<a href="http://dx.doi.org/10.2174/0929867324666171009122612" target="_blank" >http://dx.doi.org/10.2174/0929867324666171009122612</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/0929867324666171009122612" target="_blank" >10.2174/0929867324666171009122612</a>

Result language
angličtina
Original language name
Click Reactions in Chemistry of Triterpenes – Advances Towards Development of Potential Therapeutics
Original language description
Triterpenoids are natural compounds with a large variety of biological activities such as anticancer, antiviral, antibacterial, antifungal, antiparazitic, antiinflammatory and others. Despite their low toxicity and simple availability from the natural resources, their clinical use is still severely limited by their higher IC50 and worse pharmacological properties than in the currently used therapeutics. This fact encouraged a number of researchers to develop new terpenic derivatives more suitable for the potential clinical use. This review summarizes a new approach to improve both, the activity and ADME-Tox properties by connecting active terpenes to another modifying molecules using click reactions. Within the past few years, this synthetic approach was well explored yielding a lot of great improvements of the parent compounds along with some less successful attempts. A large quantity of the new compounds presented here are superior in both activity and ADME-Tox properties to their parents. This review should serve the researchers who need to promote their hit triterpenic structures towards their clinical use and it is intended as a guide for the chemical synthesis of better drug candidates.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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