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Modification of Liposomal Surface by Polysaccharides: Preparation, Characterization and Application for Drug Targeting

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73593026" target="_blank" >RIV/61989592:15110/19:73593026 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/B9780081025550000133" target="_blank" >https://www.sciencedirect.com/science/article/pii/B9780081025550000133</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/B978-0-08-102555-0.00013-3" target="_blank" >10.1016/B978-0-08-102555-0.00013-3</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Modification of Liposomal Surface by Polysaccharides: Preparation, Characterization and Application for Drug Targeting

  • Original language description

    Polysaccharides are indispensable macromolecules widely used in pharmaceutical industry. Hyaluronic acid, mannans, cellulose derivatives, alginates and, dextrans are applied for preparation of polysaccharide-modified nanoparticles to develop targeted delivery systems for drugs, theranostics, vaccines and immunotherapeutics. Liposomes represent the most versatile nanoparticles and liposomal products have already found clinical applications, due to their biocompatibility, biodegradability, low toxicity and ability to internalize substances with different physical-chemical properties. Modification of liposomal surface with polysaccharides is a special part of bioconjugation chemistry and application of click chemistry for orthogonal binding of polysaccharides onto liposomal surface is new challenging approach for development of drug and vaccine targeting nanosystems. New technologies for laboratory and industrial production of polysaccharide-modified liposomes can be developed by combination of microfluidics technology integrated together with other processes (dialysis, click chemistry, photochemistry, and drug loading) into a single device by utilizing so-called Lab-on-Chip technology enabling automated high-throughput processes for production of liposome-based products.

  • Czech name

  • Czech description

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

  • OECD FORD branch

    10404 - Polymer science

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Functional Polysaccharides for Biomedical Applications

  • ISBN

    978-0-08-102555-0

  • Number of pages of the result

    35

  • Pages from-to

    433-467

  • Number of pages of the book

    526

  • Publisher name

    Woodhead Publishing

  • Place of publication

    Anglie

  • UT code for WoS chapter