Observation of lubrication mechanisms in knee replacement: A pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73593097" target="_blank" >RIV/61989592:15110/19:73593097 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26210/19:PU131064

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2352573818300416#" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2352573818300416#</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biotri.2019.02.001" target="_blank" >10.1016/j.biotri.2019.02.001</a>

Result language

angličtina

Original language name

Observation of lubrication mechanisms in knee replacement: A pilot study

Original language description

The present study introduces a unique experimental approach for in situ observation of lubricant film formation in knee joint replacements. A knee joint simulator was designed and equipped with optical module based on fluorescent optical method for film thickness observation. The contact between the femoral knee metal implant and real-shaped polymer insert mimicking actual contact nature is observed. The shape of the polymer insert was fabricated with respect to the shape of original polyethylene insert to ensure corresponding contact conformity. Simple solutions of albumin and γ-globulin proteins as well as its mixture were used while the film thickness was studied as a function of time considering simplified flexion/extension motion with variable load over the cycle. Adequate fluorescent markers were employed enabling to observe one particular protein during each measurement. The results showed a clear importance of the interaction of proteins since the mixtures showed different results compared to simple solutions. Especially considering albumin protein, its behaviour was substantially affected by adding γ-globulin. Moreover, a satisfactory compliance with previous findings related to hip joint lubrication in terms of the behaviour of both proteins was found. Finally, the motivation for future experimental work is highlighted.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30404 - Biomaterials (as related to medical implants, devices, sensors)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biotribology

ISSN

2352-5738

e-ISSN

—

Volume of the periodical

71

Issue of the periodical within the volume

February

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

1-7

UT code for WoS article

—

EID of the result in the Scopus database

2-s2.0-85061051598