Cdc7 kinase stimulates Aurora B kinase in M-phase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73599271" target="_blank" >RIV/61989592:15110/19:73599271 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41598-019-54738-2.pdf" target="_blank" >https://www.nature.com/articles/s41598-019-54738-2.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-019-54738-2" target="_blank" >10.1038/s41598-019-54738-2</a>
Alternative languages
Result language
angličtina
Original language name
Cdc7 kinase stimulates Aurora B kinase in M-phase
Original language description
The conserved serine-threonine kinase, Cdc7-Dbf4, phosphorylates Mcm in the pre-Replicative Complex (pre-RC) and facilitates recruitment of other replication factors including Cdc45 for initiation of DNA replication1–8. Cdc7 forms a complex with an activation subunit, Dbf4/ASK, to become an active kinase9–11. Cdc7 also plays a role in activation of replication checkpoint pathway (ATR-Claspin-Chk1 pathway in vertebrates12–16). Recent studies show that Cdc7 kinase plays roles in various chromosome transactions including meiotic recombination, meiosis, trans-lesion DNA synthesis, and histone modifcation17,18. Cdc7 also interacts with various chromosome markers including HP1 that recognizes methylated lysine 9 of histone H3 and with centromere proteins19,20. Cdc7 also phosphorylates Histone H3 at threonine-45 as a part of replication stress responses21.
Czech name
—
Czech description
—
Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
—
Volume of the periodical
9
Issue of the periodical within the volume
09.12.2019
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
"nestránkováno"
UT code for WoS article
000501757000002
EID of the result in the Scopus database
2-s2.0-85076336995