Regulation and roles of Cdc7 kinase under replication stress

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33149709" target="_blank" >RIV/61989592:15110/14:33149709 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.4161/cc.29251" target="_blank" >http://dx.doi.org/10.4161/cc.29251</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4161/cc.29251" target="_blank" >10.4161/cc.29251</a>

Result language

angličtina

Original language name

Regulation and roles of Cdc7 kinase under replication stress

Original language description

Cdc7 (cell division cycle 7) kinase together with its activation subunit ASK (also known as Dbf4) play pivotal roles in DNA replication and contribute also to other aspects of DNA metabolism such as DNA repair and recombination. While the biological significance of Cdc7 is widely appreciated, the molecular mechanisms through which Cdc7 kinase regulates these various DNA transactions remain largely obscure, including the role of Cdc7-ASK/ Dbf4 under replication stress, a condition associated with diverse(patho) physiological scenarios. In this review, we first highlight the recent findings on a novel pathway that regulates the stability of the human Cdc7-ASK/ Dbf4 complex under replication stress, its interplay with ATR-Chk1 signaling, and significancein the RAD18-dependent DNA damage bypass pathway. We also consider Cdc7 function in a broader context, considering both physiological conditions and pathologies associated with enhanced replication stress, particularly oncogenic transfor

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell cycle

ISSN

1538-4101

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

1859-1866

UT code for WoS article

000337944100009

EID of the result in the Scopus database

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