Comparison of inflammatory biomarker levels in neurodegenerative proteinopathies: a case-control study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F25%3A73630984" target="_blank" >RIV/61989592:15110/25:73630984 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/25:10159295

Result on the web

<a href="https://link.springer.com/article/10.1007/s00702-025-02902-6" target="_blank" >https://link.springer.com/article/10.1007/s00702-025-02902-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-025-02902-6" target="_blank" >10.1007/s00702-025-02902-6</a>

Result language

angličtina

Original language name

Comparison of inflammatory biomarker levels in neurodegenerative proteinopathies: a case-control study

Original language description

While diagnostic criteria have been established and validated for most neurodegenerative diseases, the considerable overlap between individual nosological entities remains a significant diagnostic challenge. Increasing evidence suggests that neurodegeneration is often initiated by inflammation within the central nervous system. The identification of inflammation could serve as a first signal of the pathophysiological process. As such, validated biological markers (&quot;biomarkers&quot;) of neuroinflammation are critically important. This study aimed to assess the presence and levels of inflammatory biomarkers in three neurodegenerative diseases: Lewy body diseases (LBD), multiple system atrophy (MSA), and 4-repeat tauopathies (4RT). A total of 83 LBD, 24 MSA, and 31 4RT patients were included, with 83 control subjects for comparison. Six immune-related proteins were analysed in cerebrospinal fluid (CSF) and blood serum (serum): C3 complement, C4 complement, haptoglobin, transferrin, orosomucoid, and beta 2 microglobulin (beta 2M). ANCOVA statistical analysis revealed significantly lower levels of several inflammatory biomarkers in LBD (CSF: transferrin, C3 complement, orosomucoid; Serum: orosomucoid, beta 2M) and MSA (CSF: transferrin, C3 complement, C4 complement, orosomucoid) compared to controls. Significant differences were also observed between the synucleinopathy patient groups (LBD and MSA) and 4RT in serum levels of C3 complement. Additionally, the CSF/serum quotients for transferrin (LBD and MSA) and C3 complement (LBD) were significantly lower in disease relative to controls. These findings suggest that inflammatory processes may play a role in the pathophysiology of neurodegenerative proteinopathies, warranting further research to confirm these associations. The identification of potential fluid biomarkers would then represent a promising step forward in the field.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

<a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF NEURAL TRANSMISSION

ISSN

0300-9564

e-ISSN

1435-1463

Volume of the periodical

132

Issue of the periodical within the volume

6

Country of publishing house

AT - AUSTRIA

Number of pages

16

Pages from-to

811-826

UT code for WoS article

001435518200001

EID of the result in the Scopus database

2-s2.0-86000356574