The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F03%3A00001601" target="_blank" >RIV/61989592:15310/03:00001601 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest

Original language description

The activity of cyclin-dependent kinases (CDK), the key regulators of the cell cycle, is strictly controlled by different mechanisms but is often altered in human cancer. This has stimulated the search for molecules targeting CDK activity as anti-canceragents. Different types of CDK inhibitors have been described, among them, C2-, N6-, N9-substituted purines such as plant cytokinin analogues. We have previously reported the inhibition of CDK1 and CDK2 activity by a new group of plant cytokinin analogu es (Vermeulen et al., Leukemia 2001;16:299). These compounds inhibit proliferation of leukemic cell lines and induce apoptosis, which is initiated by the mitochondrial pathway (Vermeulen et al., Experimen Hemat 2002;30:1107). In this study, the mechanismof CDK inhibitor-induced apoptosis was further characterized. The expression of two Bcl-2 family members (Bcl-2 and Bax) was examined in malignant hematopoietic cell lines after treatment with CDK inhibitors. Bcl-2 prolongs cell survival

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

ED - Physiology

OECD FORD branch

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Project

<a href="/en/project/GA301%2F02%2F0475" target="_blank" >GA301/02/0475: Purine inhibitors of cyclin-dependent kinases as anticancer and antimitotic compounds</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Experimental Hematology

ISBN

0301-472X

ISSN

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e-ISSN

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Number of pages

246

Pages from-to

207

Publisher name

Elsevier

Place of publication

New York

Event location

Paris, France

Event date

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Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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