Energetics, conformation, and recognition of DNA duplexes modified by methylated analogues of [PtCl(dien)]+. Chem Eur J, 15, 6211-6221.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F09%3A00010123" target="_blank" >RIV/61989592:15310/09:00010123 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Energetics, conformation, and recognition of DNA duplexes modified by methylated analogues of [PtCl(dien)]+. Chem Eur J, 15, 6211-6221.

Original language description

We recently synthesized and characterized water-soluble dinuclear RuII arene complexes, in which two {(6-p-isopropyltoluene)RuCl[3-(oxo-O)-2-methyl-4-pyridinonato-O4]} units were linked by flexible chains of different length [(CH2)n (n = 4, 6, 8, 12)]. These new dinuclear ruthenium drugs were found to exert promising cytotoxic effects in human cancer cells. In the present work DNA modifications by these new dinuclear RuII arene compounds, which differed in the length of the linker between the two RuII centers, were examined by biochemical and biophysical methods. The complexes bind DNA forming intrastrand and interstrand cross-links in one DNA molecule in the absence of proteins. An intriguing aspect of the DNA-binding mode of these dinuclear RuII compounds is that they can crosslink two DNA duplexes and also proteins to DNA?a feature not observed for other antitumor ruthenium complexes. Thus, the concept for the design of interhelical and DNA? protein cross-linking agents based on din

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

<a href="/en/project/OC09018" target="_blank" >OC09018: Mechanism of antitumor activity of metallodrugs. DNA replication and repair of DNA damage</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemistry: A European Journal

ISSN

0947-6539

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

25

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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