Interaction of antitumor platinum complexes with human liver microsomal cytochromes P450.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F09%3A00010316" target="_blank" >RIV/61989592:15310/09:00010316 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/09:00337635 RIV/61989592:15110/09:00009616

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Interaction of antitumor platinum complexes with human liver microsomal cytochromes P450.

Original language description

Interaction of nine human hepatic cytochromes P450 (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4) with six platinum complexes was studied using pooled human microsomes. The compounds used were cisplatin, oxaliplatin, carboplatin, transplatin, and trans-[PtCl2(NH3) (Am)], where Am=2-methylbutylamine or sec-butylamine. No significant inhibition of all CYP activities by carboplatin was observed. With cisplatin and oxaliplatin, a minor inhibition of CYP2C9 enzyme (75% of control at 400 ?mol/l of these complexes) was seen; cisplatin also inhibited slightly the CYP2B6 activity (85% of control). With respect to plasma levels of cisplatin obtained in clinical applications, these effects are probably not important. In contrast, clinically ineffective transplatin, inhibited the CYP2B6 as well as CYP2C9 activities significantly (to 50-35% of control at 100 ?mol/l); also, an inhibition of CYP2E1 activity was found here (to 70% at 100 ?mol/l). Two other derivatives of

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/KAN200200651" target="_blank" >KAN200200651: Nanoparticulate and supramolecular systems for targeted drug delivery</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anti-cancer Drugs

ISSN

0959-4973

e-ISSN

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Volume of the periodical

20

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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