Efficient Synthesis and Cytotoxic Activity of Some Symmetrical Disulfides Derived from the Quinolin-4(1H)-one Skeleton
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F09%3A00010463" target="_blank" >RIV/61989592:15310/09:00010463 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Efficient Synthesis and Cytotoxic Activity of Some Symmetrical Disulfides Derived from the Quinolin-4(1H)-one Skeleton
Original language description
The preparation of novel organic disulfides containing the 2-(substituted phenyl)quinolin-4(1H)-one ring is described. The synthesis starts from thioanthranilic acid esterified with various bromoacetophenones. Cyclization of the resulting phenacyl thioanthranilates in trifluoroacetic acid afforded a mixture of 2-(substituted phenyl)-3-sulfanylquinolin-4(1H)- ones and 3,3-disulfanediylbis[2-(substituted phenyl)quinolin- 4(1H)-ones]. Heating of the mixture in o-xylene gave 3,3-disulfanediylbis[2-(substituted phenyl)quinolin-4(1H)-ones] of high purity. The disulfides exhibited a significant in vitro cytotoxicity against various cancer cell lines including polyresistant subclones. The data obtained are reported and discussed.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LC07017" target="_blank" >LC07017: Oncoproteomics Centre</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Organic chemistry
ISSN
1099-0690
e-ISSN
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Volume of the periodical
2009
Issue of the periodical within the volume
23
Country of publishing house
DE - GERMANY
Number of pages
4
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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