Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F10%3A10212649" target="_blank" >RIV/61989592:15310/10:10212649 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/10:10212649 RIV/61389030:_____/10:00349828
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use
Original language description
This invention relates to new disubstituted pyrazolo[4,3-d]pyrimidine derivatives and to their use in suitable utilities, especially in cancer therapy and agricultural practice. The compounds are antimitotic, anticancer, herbicidal, fungicidal and insecticidal having improved selectivity and efficiency index, i.e. that are less toxic yet more efficacious than analogues known. It is an object of this invention to provide 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide a method for inhibiting cell proliferation and inflammatory diseases to a mammal in need of an effective amount 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines.The solutionof this object are 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines of the formula I.
Czech name
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Czech description
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Classification
Type
P - Patent
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Patent/design ID
EP1475094
Publisher
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Publisher name
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Place of publication
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Publication country
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Date of acceptance
Jul 28, 2010
Owner name
Ústav experimentalni botaniky Akademie věd České republiky, Univerzita Palackého v Olomouci
Method of use
B - Výsledek je využíván orgány státní nebo veřejné správy
Usage type
A - K využití výsledku jiným subjektem je vždy nutné nabytí licence