Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F10%3A10212654" target="_blank" >RIV/61989592:15310/10:10212654 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/10:00349834
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy
Original language description
The invention relates to new trisubstituted pyrazolo[4,3-d]pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods.The compounds are anticancer, anti-inflammatory, antiviral, antineurodegenerative, neurodepressive and immunosuppressive, they have improved selectivity and efficiency index, i.e. that are less toxic yet more efficacious than analogues known.It is an object of this invention to provide 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines,which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide a method for inhibiting cell proliferation and inflammatory diseases to a mammal in need of an effective amount.The solution of this object are 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines of the formula I.
Czech name
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Czech description
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Classification
Type
P - Patent
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Patent/design ID
US7745450
Publisher
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Publisher name
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Place of publication
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Publication country
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Date of acceptance
Jun 29, 2010
Owner name
Institute of Experimental Botany, Prague (CZ), Univerzita Palackeho v Olomouci, Olomouc (CZ)
Method of use
B - Výsledek je využíván orgány státní nebo veřejné správy
Usage type
A - K využití výsledku jiným subjektem je vždy nutné nabytí licence