How to modify 7-azaindole to form cytotoxic Pt(II) complexes: Highly in vitro anticancer effective cisplatin derivatives involving halogeno-substituted 7-azaindole

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33140832" target="_blank" >RIV/61989592:15310/12:33140832 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/12:00386052
Result on the web
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2012.05.006" target="_blank" >http://dx.doi.org/10.1016/j.jinorgbio.2012.05.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2012.05.006" target="_blank" >10.1016/j.jinorgbio.2012.05.006</a>

Result language
angličtina
Original language name
How to modify 7-azaindole to form cytotoxic Pt(II) complexes: Highly in vitro anticancer effective cisplatin derivatives involving halogeno-substituted 7-azaindole
Original language description
The platinum(II) dichlorido and oxalato complexes of the general formula cis-[PtCl2(nHaza)(2)] (1-3) [Pt(ox)(nHaza)(2)] (4-6) involving 7-azaindole halogeno-derivatives (nHaza) were prepared and thoroughly characterized. A single-crystal X-ray analysis of cis-[PtCl2(3ClHaza)(2)].DMF (1.DMF: 3ClHaza symbolizes 3-chloro-7-azaindole) revealed a distorted square-planar arrangement with both the 3ClHaza molecules coordinated through their N7 atoms in a cis fashion. In vitro cytotoxicity of the complexes wasevaluated by an MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay against the HOS (osteosarcoma), MCF7 (breast adenocarcinoma) and LNCaP (prostate adenocarcinoma) human cancer cell lines. The dichlorido complexes 1-3 (IC50 = 3.8, 3.9, and 2.5 uM, respectively) showed significantly higher in vitro anticancer effect against HOS as compared with cisplatin, whose IC50 = 37.7 uM. The biological effect of cisplatin against MCF7 (IC50 = 24.5 uM) and LNCaP (IC50 = 3.8 uM)
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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