Synthesis, X-ray structures, properties and SOD-like activity of ternary copper(II) complexes showing the N4O2 coordination with a combination of monodentate and bidentate N-donor ligands

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33140881" target="_blank" >RIV/61989592:15310/12:33140881 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0020169311009455" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0020169311009455</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ica.2011.11.021" target="_blank" >10.1016/j.ica.2011.11.021</a>

Result language
angličtina
Original language name
Synthesis, X-ray structures, properties and SOD-like activity of ternary copper(II) complexes showing the N4O2 coordination with a combination of monodentate and bidentate N-donor ligands
Original language description
A series of novel copper(II) complexes with the composition of [Cu(H2O)(2)(L1-5)(2)(phen)].2MeOH (1-5), where HL1 = 6-(2-fluorobenzylamino) purine, HL2 = 6-(3-fluorobenzylamino) purine, HL3 = 6-(4-fluorobenzylamino) purine, HL4 = 6-(2-chlorobenzylamino)purine, HL5 = 6-(3-chlorobenzylamino) purine, phen = 1,10-phenanthroline, was synthesized and characterized by elemental analysis, electronic and infrared spectroscopy, magnetic and conductivity measurements. Single-crystal X-ray analysis of complexes 1-4showed the distorted octahedral geometry in the vicinity of the copper(II) atom, which is coordinated by four nitrogen atoms (two from the bidentate phen ligand and the other two from monodentate 6-(benzylamino) purine derivatives) and two oxygen atomsfrom the aqua ligands, which together form the N4O2 donor set. The antiradical activity of the prepared complexes was tested by an in vitro SOD-like assay. The IC50 values were found ranging between 104 and 146 uM, which represents ca. 0.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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