Synthesis and cytotoxic activities of estrone and estradiol cis-dichloroplatinum(II) complexes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33142805" target="_blank" >RIV/61989592:15310/12:33142805 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/12:00384104 RIV/61388963:_____/12:00384104
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0968089612008231" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0968089612008231</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bmc.2012.10.013" target="_blank" >10.1016/j.bmc.2012.10.013</a>

Result language
angličtina
Original language name
Synthesis and cytotoxic activities of estrone and estradiol cis-dichloroplatinum(II) complexes
Original language description
Sixteen platinum(II) complexes of estrone and estradiol were synthesized in this work to evaluate their cytotoxic activity against several cancer cell lines including estrogen dependent and independent ones. The synthesis of all the complexes was done inthree steps. The reaction of steroids with dibromoalkanes was followed by a reaction of the bromoalkyl steroids with 2-(aminomethyl) pyridine or 2-(2-aminoethyl) pyridine. The last step was a reaction of steroidal diamino ligands with potassium tetrachloroplatinate to obtain the desired platinum(II) complexes. Cytotoxicity assays showed that most of the complexes prepared are active against the cancer cell lines used-CEM, U-2 OS, MCF7, MCF7 AL, MDA-MB-468, BT-474, BT-549, and BJ fibroblasts. The six-membered platinum complexes are more active than five-membered ones.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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