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Polyamine conjugates of stigmasterol

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33142892" target="_blank" >RIV/61989592:15310/12:33142892 - isvavai.cz</a>

  • Alternative codes found

    RIV/61389030:_____/12:00380984 RIV/61388963:_____/12:00380984 RIV/60461373:22330/12:43894134

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S0039128X12002073" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0039128X12002073</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.steroids.2012.07.009" target="_blank" >10.1016/j.steroids.2012.07.009</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Polyamine conjugates of stigmasterol

  • Original language description

    Three new polyamine conjugates with stigmasterol [(3 beta,22E)-stigmasta-5,22-dien-3-ol] were synthesized and subjected to basic antimicrobial and cytotoxic tests. The conjugate derived from spermine, (3 beta,22E)-stigmasta-5,22-dien-3-yl 4(12-amino-4,9-diaza-dodecylamino)-4-oxobutanoate (5c), displayed considerable antimicrobial activity on Staphylococcus aureus at low concentration (50 mu g mL(-1)). The cytotoxic activity was tested on cells of human T-Iymfoblastic leukemia (IC50 = 35.8 +/- 10.3 mu M(5c) and IC50 = 35.9 +/- 5.7 mu M (5b)) and normal human fibroblasts (IC50 = 38.0 +/- 2.8 mu M (5c) and IC50= 45.5 +/- 1.9 mu M (5b)). Conjugate Sa displayed no activity in both tests

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Steroids

  • ISSN

    0039-128X

  • e-ISSN

  • Volume of the periodical

    77

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    1212-1218

  • UT code for WoS article

    000310480800005

  • EID of the result in the Scopus database