Lipid Bilayer Membrane Affinity Rationalizes Inhibition of Lipid Peroxidation by a Natural Lignan Antioxidant
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33145676" target="_blank" >RIV/61989592:15310/13:33145676 - isvavai.cz</a>
Result on the web
<a href="http://pubs.acs.org/doi/abs/10.1021/jp3127829" target="_blank" >http://pubs.acs.org/doi/abs/10.1021/jp3127829</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/jp3127829" target="_blank" >10.1021/jp3127829</a>
Alternative languages
Result language
angličtina
Original language name
Lipid Bilayer Membrane Affinity Rationalizes Inhibition of Lipid Peroxidation by a Natural Lignan Antioxidant
Original language description
Lipid peroxidation is a degenerative oxidative process that modifies the structure of membranes, influencing their :biological functions.,Lignans, natural polyphenolic antioxidants widely distributed in plants, can prevent this membrane damage by free radical scavenging. Here,: we rationalize the difference in lipid peroxidation inhibition activity of argenteane, a natural dilignan isolated from Wild nutmeg, and 3,3'-dirriethoxy-1,1'-biphenyl-2,2'-diol, which represents the central part of argenteane responsible for its antioxidant activity. Although both compounds have the same capacity to scavenge free radicals, argenteane is a more active inhibitor of lipid peroxidation. We show that both compounds penetrate into DOPc and PLPC lipid bilayers and adopt similar positions and orientations, which therefore does not explain the difference in their lipid peroxidation inhibition activity: However, free energy profiles indicate that argenteane has a significantly higher affinity to the lipi
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Physical Chemistry B
ISSN
1520-6106
e-ISSN
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Volume of the periodical
117
Issue of the periodical within the volume
17
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
5043-5049
UT code for WoS article
000318536700033
EID of the result in the Scopus database
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