Influence of Hydrogencalcium Salts of Oxidized Cellulose on MMP-2, MMP-9 and TNF-alfa Production and Wound Healing in Non-Healing Wounds

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33146181" target="_blank" >RIV/61989592:15310/13:33146181 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/13:33146181

Result on the web

<a href="http://adc.mef.hr/index.php/adc/article/view/1008" target="_blank" >http://adc.mef.hr/index.php/adc/article/view/1008</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Influence of Hydrogencalcium Salts of Oxidized Cellulose on MMP-2, MMP-9 and TNF-alfa Production and Wound Healing in Non-Healing Wounds

Original language description

Levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and tumor necrosis factor-alfa (TNF-alfa) may influence wound healing and wound closure in non-healing wounds. The aim of the study was to test the hypothesis that hydrogencalcium salts of oxidized cellulose change the production of matrix metalloproteinases (MMPs) and TNF-alfa, wound size and number of bacterial strains in non-healing wounds. We analyzed MMP-2, MMP-9 and TNF-alfa in the wound fluid from 20 patients by ELISA every fourteen days over six weeks. Wound size, pain, wound closure and bacterial strains in the wound were also investigated. The wound size was reduced in 14 patients and pain in 16 patients. Bacterial contamination of the wound decreased significantly after treatment. The level of MMP-2 correlated with TNF-alfa production. The level of MMP-9 was unchanged during the healing period. We conclude that hydrogencalcium salts of oxidized cellulose have a favorable effect on the reduction

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Dermatovenerologica Croatica

ISSN

1330-027X

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

4

Country of publishing house

HR - CROATIA

Number of pages

5

Pages from-to

219-223

UT code for WoS article

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EID of the result in the Scopus database

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