4?Chloro-2-Fluoro-5-Nitrobenzoic Acid as a Possible Building Block for Solid-phase Synthesis of Various Heterocyclic Scaffolds

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33147690" target="_blank" >RIV/61989592:15310/13:33147690 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1021/co300109h" target="_blank" >http://dx.doi.org/10.1021/co300109h</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/co300109h" target="_blank" >10.1021/co300109h</a>

Result language

angličtina

Original language name

4?Chloro-2-Fluoro-5-Nitrobenzoic Acid as a Possible Building Block for Solid-phase Synthesis of Various Heterocyclic Scaffolds

Original language description

4-Chloro-2-fluoro-5-nitrobenzoic acid is a commercially available multireactive building block that can serve as a starting material in heterocyclic oriented synthesis (HOS)leading to various condensed nitrogenous cycles. This work describes its abilityfor the preparation of substituted nitrogenous heterocycles having 5?7-membered cycles via polymer-supported o-phenylendiamines. Immobilization of this compound on Rink resin followed by further chlorine substitution, reduction of a nitro group and appropriate cyclization afforded benzimidazoles,benzotriazoles, quinoxalinones,benzodiazepinediones and succinimides. The method developed is suitable for the synthesis of diverse libraries including the mentioned types of heterocycles, which have significantimportance in current drug discovery. In this paper, we also report limitation of these method and unsuccessful attempt to prepare an 8-membered benzodiazocine cycle.""

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACS Combinatorial Science

ISSN

2156-8952

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

20-28

UT code for WoS article

000313605600004

EID of the result in the Scopus database

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