Adjusting the DNA interaction and anticancer activity of Pt(II) N-heterocyclic carbene complexes by steric shielding of the trans leaving group
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33155825" target="_blank" >RIV/61989592:15310/15:33155825 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/15:00447636
Result on the web
<a href="http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00896" target="_blank" >http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00896</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.jmedchem.5b00896" target="_blank" >10.1021/acs.jmedchem.5b00896</a>
Alternative languages
Result language
angličtina
Original language name
Adjusting the DNA interaction and anticancer activity of Pt(II) N-heterocyclic carbene complexes by steric shielding of the trans leaving group
Original language description
Five platinum(II) complexes bearing a (1,3-dibenzyl)imidazol-2-ylidene ligand but different leaving groups trans to it were examined for cytotoxicity, DNA and cell cycle interference, vascular disrupting properties, and nephrotoxicity. The results showedthat only platinum(II) complexes with good leaving groups such as chloride trans to the N-heterocyclic carbene ligand interact noticeably with DNA. However, this is not a prerequisite for high cytotoxicity against cancer cells
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA14-21053S" target="_blank" >GA14-21053S: Mechanistic studies on dual targeting of DNA and histone deacetylase with bifunctional inhibitors</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Medicinal Chemistry
ISSN
0022-2623
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
15
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
6283-6292
UT code for WoS article
000359683700040
EID of the result in the Scopus database
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