Preparation of 2-Phenyl-3-hydroxyquinoline-4(1H)-one-5-carboxamides as Potential Anticancer and Fluorescence Agents

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156130" target="_blank" >RIV/61989592:15310/15:33156130 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/15:33156130
Result on the web
<a href="http://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra08733c" target="_blank" >http://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra08733c</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c5ra08733c" target="_blank" >10.1039/c5ra08733c</a>

Result language
angličtina
Original language name
Preparation of 2-Phenyl-3-hydroxyquinoline-4(1H)-one-5-carboxamides as Potential Anticancer and Fluorescence Agents
Original language description
Synthesis of 3-hydroxyquinoline-4(1H)-one derivatives bearing substituted phenyl in position 2 and variously substituted carboxamide group in position 5 is described, with use of 3-nitrophthalic anhydride, ?-haloketones and primary amines as the startingmaterials. The synthetic approach was inspired by the preparation of analogous derivatives reported previously. However, a different strategy had to be developed with the corresponding bis(phenacyl)-3-aminophthalates as the key intermediates . Synthesized hydroxyquinolinones, as well as their intermediates, were tested for their cytotoxic activity towards various cancer and non-malignant cell lines. The fluorescent properties of these compounds have also been evaluated. In both fields, interesting datawere obtained and compared to isomeric compounds that have been studied in the past.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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