Intact cell mass spectrometry as a progress tracking tool for batch and fed-batch fermentation processes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156912" target="_blank" >RIV/61989592:15310/15:33156912 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0003269714004655" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0003269714004655</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ab.2014.10.008" target="_blank" >10.1016/j.ab.2014.10.008</a>

Result language
angličtina
Original language name
Intact cell mass spectrometry as a progress tracking tool for batch and fed-batch fermentation processes
Original language description
Penicillin production during a fermentation process using industrial strains of Penicillium chrysogenum is a research topic permanently discussed since the accidental discovery of the antibiotic. Intact cell mass spectrometry (ICMS) can be a fast and novel monitoring tool for the fermentation progress during penicillin V production in a nearly real-time fashion. This method is already used for the characterization of microorganisms and the differentiation of fungal strains; therefore, the application ofICMS to samples directly harvested from a fermenter is a promising possibility to get fast information about the progress of fungal growth. After the optimization of the ICMS method to penicillin V fermentation broth samples, the obtained ICMS data wereevaluated by hierarchical cluster analysis or an in-house software solution written especially for ICMS data comparison. Growth stages of a batch and fed-batch fermentation of Penicillium chrysogenum are differentiated by one of those st
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
<a href="/en/project/7AMB12AT018" target="_blank" >7AMB12AT018: Biotyping of phytopathogens of cultivated plants using mass spectrometry and identification of protein markers of infection</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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