Dinuclear metal(II)-acetato complexes based on bicompartmental 4-chlorophenolate: syntheses, structures, magnetic properties, DNA interactions and phosphodiester hydrolysis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F16%3A33161122" target="_blank" >RIV/61989592:15310/16:33161122 - isvavai.cz</a>

Result on the web

<a href="http://pubs.rsc.org/en/content/articlepdf/2016/dt/c6dt02596j" target="_blank" >http://pubs.rsc.org/en/content/articlepdf/2016/dt/c6dt02596j</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c6dt02596j" target="_blank" >10.1039/c6dt02596j</a>

Result language

angličtina

Original language name

Dinuclear metal(II)-acetato complexes based on bicompartmental 4-chlorophenolate: syntheses, structures, magnetic properties, DNA interactions and phosphodiester hydrolysis

Original language description

A series of dinuclear metal(II)-acetato complexes: [Ni-2(mu-(LO)-O-Cl)(mu(2)-OAc)(2)](PF6)center dot 3H(2)O (1), [Ni-2(mu-(LO)-O-Cl)(mu(2)-OAc)(2)](ClO4)center dot CH3COCH3 (2), [Cu-2(mu-(LO)-O-Cl)(mu(2)-OAc)(ClO4)](ClO4) (3), [Cu-2(mu-(LO)-O-Cl)(OAc)(2)](PF6)center dot H2O (4), [Zn-2(mu-(LO)-O-Cl)(mu(2)-OAc)(2)](PF6) (5) and [Mn-2(L-Cl-O)(mu(2)-OAc)(2)](ClO4)center dot H2O (6), where (LO-)-O-Cl = 2,6-bis[bis(2-pyridylmethyl)aminomethyl]-4-chlorophenolate, were synthesized. The complexes were structurally characterized by spectroscopic techniques and single crystal X-ray crystallography. Six-coordinate geometries with doubly bridged acetato ligands were found in Ni(II), Zn(II) and Mn(II) complexes 1, 2, 5 and 6, whereas with Cu(II) complexes a five-coordinate species was obtained with 4, and mixed five-and six-coordinate geometries with a doubly bridged dimetal core were observed in 3. The magnetic properties of complexes 1-4 and 6 were studied at variable temperatures and revealed weak to very weak antiferromagnetic interactions in 1, 2, 4 and 6 (J = -0.55 to -9.4 cm(-1)) and ferromagnetic coupling in 3 (J = 15.4 cm(-1)). These results are consistent with DFT calculations performed at the B3LYP/def2-TZVP(-f) level of theory. Under physiological conditions, the interaction of the dinculear complexes 1-5 with supercoiled plasmid ds-DNA did not show any pronounced nuclease activity, but Ni(II) complexes 1 and 2 revealed a strong ability to unwind the supercoiled conformation of ds-DNA. The mechanistic studies performed on the interaction of the Ni(II) complexes with DNA demonstrated the important impact of the nickel(II) ion in the unwinding process. In combination with the DNA study, the phosphatase activity of complexes 1, 3, and 5 was examined by the phosphodiester hydrolysis of bis(2,4-dinitrophenol) phosphate (BDNPP) in the pH range of 5.5-10.5 at 25 degrees C.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CA - Inorganic chemistry

OECD FORD branch

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Project

<a href="/en/project/LO1305" target="_blank" >LO1305: Development of the center of advanced technologies and materials</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Dalton Transactions (print)

ISSN

1477-9226

e-ISSN

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Volume of the periodical

45

Issue of the periodical within the volume

32

Country of publishing house

GB - UNITED KINGDOM

Number of pages

18

Pages from-to

12933-12950

UT code for WoS article

000381478500040

EID of the result in the Scopus database

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