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Identification of cisplatin-binding sites on the large cytoplasmic loop of the Na-/K--ATPase

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F18%3A73592442" target="_blank" >RIV/61989592:15310/18:73592442 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1445735" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1445735</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1080/14756366.2018.1445735" target="_blank" >10.1080/14756366.2018.1445735</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Identification of cisplatin-binding sites on the large cytoplasmic loop of the Na-/K--ATPase

  • Original language description

    Cisplatin is the most widely used chemotherapeutic drug for the treatment of various types of cancer; however, its administration brings also numerous side effects. It was demonstrated that cisplatin can inhibit the Na+/K+-ATPase (NKA), which can explain a large part of the adverse effects. In this study, we have identified five cysteinyl residues (C452, C456, C457, C577, and C656) as the cisplatin binding sites on the cytoplasmic loop connecting transmembrane helices 4 and 5 (C45), using site-directed mutagenesis and mass spectrometry experiments. The identified residues are known to be susceptible to glutathionylation indicating their involvement in a common regulatory mechanism.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10610 - Biophysics

Result continuities

  • Project

    <a href="/en/project/LO1204" target="_blank" >LO1204: Sustainable development of research in the Centre of the Region Haná</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

  • ISSN

    1475-6366

  • e-ISSN

  • Volume of the periodical

    33

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    6

  • Pages from-to

    701-706

  • UT code for WoS article

    000428584800001

  • EID of the result in the Scopus database

    2-s2.0-85044747825