Identification of cisplatin-binding sites on the large cytoplasmic loop of the Na-/K--ATPase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F18%3A73592442" target="_blank" >RIV/61989592:15310/18:73592442 - isvavai.cz</a>
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1445735" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1445735</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/14756366.2018.1445735" target="_blank" >10.1080/14756366.2018.1445735</a>
Alternative languages
Result language
angličtina
Original language name
Identification of cisplatin-binding sites on the large cytoplasmic loop of the Na-/K--ATPase
Original language description
Cisplatin is the most widely used chemotherapeutic drug for the treatment of various types of cancer; however, its administration brings also numerous side effects. It was demonstrated that cisplatin can inhibit the Na+/K+-ATPase (NKA), which can explain a large part of the adverse effects. In this study, we have identified five cysteinyl residues (C452, C456, C457, C577, and C656) as the cisplatin binding sites on the cytoplasmic loop connecting transmembrane helices 4 and 5 (C45), using site-directed mutagenesis and mass spectrometry experiments. The identified residues are known to be susceptible to glutathionylation indicating their involvement in a common regulatory mechanism.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/LO1204" target="_blank" >LO1204: Sustainable development of research in the Centre of the Region Haná</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
ISSN
1475-6366
e-ISSN
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Volume of the periodical
33
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
701-706
UT code for WoS article
000428584800001
EID of the result in the Scopus database
2-s2.0-85044747825