Na /K -ATPase inhibition by cisplatin and consequences for cisplatin nephrotoxicity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33150270" target="_blank" >RIV/61989592:15310/14:33150270 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/14:33150270
Result on the web
<a href="http://dx.doi.org/10.5507/bp.2014.018" target="_blank" >http://dx.doi.org/10.5507/bp.2014.018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2014.018" target="_blank" >10.5507/bp.2014.018</a>

Result language
angličtina
Original language name
Na /K -ATPase inhibition by cisplatin and consequences for cisplatin nephrotoxicity
Original language description
Unintended interactions of drugs present serious limitations to treatment success. Although a large number of membrane pumps have been identified as potential targets of cisplatin, vis-a-vis nephrotoxicity, NKA inhibition seems to be of crucial importance. Experiments with isolated large cytoplasmic segment C45 revealed that it is the main target of cisplatin on NKA and that the reaction with cysteine residues plays an important role in cisplatin/NKA interactions.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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