Clindamycin-Loaded Nanosized Calcium Phosphates Powders as a Carrier of Active Substances

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F23%3A73622846" target="_blank" >RIV/61989592:15310/23:73622846 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2079-4991/13/9/1469" target="_blank" >https://www.mdpi.com/2079-4991/13/9/1469</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nano13091469" target="_blank" >10.3390/nano13091469</a>

Result language

angličtina

Original language name

Clindamycin-Loaded Nanosized Calcium Phosphates Powders as a Carrier of Active Substances

Original language description

Bioactive calcium phosphate ceramics (CaPs) are one of the building components of the inorganic part of bones. Synthetic CaPs are frequently used as materials for filling bone defects in the form of pastes or composites; however, their porous structure allows modification with active substances and, thus, subsequent use as a drug carrier for the controlled release of active substances. In this study, four different ceramic powders were compared: commercial hydroxyapatite (HA), TCP, brushite, as well as HA obtained by wet precipitation methods. The ceramic powders were subjected to physicochemical analysis, including FTIR, XRD, and determination of Ca/P molar ratio or porosity. These techniques confirmed that the materials were phase-pure, and the molar ratios of calcium and phosphorus elements were in accordance with the literature. This confirmed the validity of the selected synthesis methods. CaPs were then modified with the antibiotic clindamycin. Drug release was determined on HPLC, and antimicrobial properties were tested against Staphylococcus aureus. The specific surface area of the ceramic has been demonstrated to be a factor in drug release efficiency.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10403 - Physical chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nanomaterials

ISSN

2079-4991

e-ISSN

2079-4991

Volume of the periodical

13

Issue of the periodical within the volume

9

Country of publishing house

CH - SWITZERLAND

Number of pages

19

Pages from-to

"1469-1"-"1469-19"

UT code for WoS article

000987556900001

EID of the result in the Scopus database

2-s2.0-85159175032