Synthesis and photodynamic activity of new 5-[(E)-2-(3-alkoxy-1-phenyl-1H-pyrazol-4-yl)ethenyl]-2-phenyl-3H-indoles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F24%3A73625374" target="_blank" >RIV/61989592:15310/24:73625374 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/ardp.202400282" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/ardp.202400282</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ardp.202400282" target="_blank" >10.1002/ardp.202400282</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis and photodynamic activity of new 5-[(E)-2-(3-alkoxy-1-phenyl-1H-pyrazol-4-yl)ethenyl]-2-phenyl-3H-indoles
Original language description
A series of new indole‐pyrazole hybrids 8a–m were synthesized through the palladium‐catalyzed ligandless Heck coupling reaction from easily accessible unsubstituted, methoxy‐ or fluoro‐substituted 4‐ethenyl‐1H‐pyrazoles and 5‐bromo‐3H‐indoles. Thesecompounds exerted cytotoxicity to melanoma G361 cells when irradiated with blue light (414 nm) and no cytotoxicity in the dark at concentrations up to 10 μM, prompting us to explore their photodynamic effects.The photodynamic properties of the example compound 8d were furthe investigated in breast cancer MCF‐7 cells. Evaluation revealed comparable anticancer activities of 8d in both breast and melanoma cancer cell lines within the submicromolar range. The treatment induced a massive generation of reactiveoxygen species, leading to different types of cell death depending on the compound concentration and the irradiation intensity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
<a href="/en/project/LX22NPO5102" target="_blank" >LX22NPO5102: National institute for cancer research</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ARCHIV DER PHARMAZIE
ISSN
0365-6233
e-ISSN
1521-4184
Volume of the periodical
357
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
20
Pages from-to
"e2400282-1"-"e2400282-20"
UT code for WoS article
001263254500001
EID of the result in the Scopus database
2-s2.0-85197544749