A Label-Free Sensor Array Based on Carbon Quantum Dots for Detection of α-Synuclein Oligomers in Saliva
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F24%3A73625727" target="_blank" >RIV/61989592:15310/24:73625727 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/epdf/10.1021/acs.analchem.4c00874" target="_blank" >https://pubs.acs.org/doi/epdf/10.1021/acs.analchem.4c00874</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.analchem.4c00874" target="_blank" >10.1021/acs.analchem.4c00874</a>
Alternative languages
Result language
angličtina
Original language name
A Label-Free Sensor Array Based on Carbon Quantum Dots for Detection of α-Synuclein Oligomers in Saliva
Original language description
Salivary oligomeric α-synuclein (α-Syn) has been introduced as a promising biomarker for the diagnosis of Parkinson’s disease. Herein, a fluorescence sensor array based on three carbon quantum dots (CQDs) with different surface functional groups was developed for the identification and quantification of salivary α-Syn oligomers. Each of the CQDs generated a different fluorescence response to the target analyte, and the responses were analyzed by NPLS-DA to create a unique response pattern for the target analyte. The developed three-element sensor array showed a linear response to α-Syn oligomers in the range of 0.5-32 μg/mL and a detection limit (LOD) of 0.5 μg/mL, with a cross-validation accuracy of 92% in aqueous solution. The sensor array could detect the analyte in a mixture of different proteins and in the complex medium of saliva, with the LOD of 0.3 μg/mL indicating the massive potential of CQD arrays for developing sensitive, simple, inexpensive, and label-free sensing platforms.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ANALYTICAL CHEMISTRY
ISSN
0003-2700
e-ISSN
1520-6882
Volume of the periodical
96
Issue of the periodical within the volume
30
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
12246-12253
UT code for WoS article
001274519900001
EID of the result in the Scopus database
2-s2.0-85199267034