An environmentally friendly wound dressing based on a self-healing, extensible and compressible antibacterial hydrogel
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F21%3A73607326" target="_blank" >RIV/61989592:15640/21:73607326 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2021/GC/D0GC02719G" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2021/GC/D0GC02719G</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d0gc02719g" target="_blank" >10.1039/d0gc02719g</a>
Alternative languages
Result language
angličtina
Original language name
An environmentally friendly wound dressing based on a self-healing, extensible and compressible antibacterial hydrogel
Original language description
The design of wound dressing hydrogels is of utmost importance in healthcare with desired remedial effects, self-healing ability, cell affinity, and appropriate mechanical properties, particularly for healing skin wounds; excellent wound tissue adhesiveness is imperative. Here, an ultra-tough and self-healable double-network (DN) hydrogel is designed based on salep/poly(vinyl alcohol) that is endowed with superior tissue adhesiveness and cell affinity as demonstrated for critical and burn wound healing in rats. The self-healing capability of the hydrogel is attained via hydrogen bonds and Schiff-base cross-linking between oxidized salep (OSa) and ethylene diamine-modified salep (SaHEA) chains (OSEA network). The interaction of hydroxyl groups of the poly(vinyl alcohol) (PVA) network effectively facilitates to create a stable mechanical structure and endow self-healing ability. The ensuing novel hydrogel is endowed with excellent self-healing ability, high mechanical strength (Young's modulus of up to 14 kPa; high fracture energy of up to 90 kJ m(-3); compressive stress of 400 kPa), good tissue adhesiveness (up to 48 N m(-1) adhesive strength), and superior therapeutic properties (cell viability of A375 cells >80%; remarkable healing of >60% in 14 and >98% in 21 days). The macroscopic evaluation revealed healing >80% in 14 days and 100% in 21 days that is achieved by combining both networks in a single system along with Arnebia extract and Ag nanoparticles (Ag NPs) in green media. In vitro and in vivo tests affirmed that the PVA/OSEA DN hydrogel could be an excellent candidate for skin tissue regeneration in medical applications.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
GREEN CHEMISTRY
ISSN
1463-9262
e-ISSN
—
Volume of the periodical
2021
Issue of the periodical within the volume
23
Country of publishing house
GB - UNITED KINGDOM
Number of pages
18
Pages from-to
1312-1329
UT code for WoS article
000618044800023
EID of the result in the Scopus database
2-s2.0-85101082097