Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F24%3A73624803" target="_blank" >RIV/61989592:15640/24:73624803 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/24:73624803 RIV/00098892:_____/24:10158704
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/med.22033" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/med.22033</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/med.22033" target="_blank" >10.1002/med.22033</a>
Alternative languages
Result language
angličtina
Original language name
Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies
Original language description
As the world population ages, there will be an increasing need for effective therapies for aging-associated neurodegenerative disorders, which remain untreatable. Dementia due to Alzheimer's disease (AD) is one of the leading neurological diseases in the aging population. Current therapeutic approaches to treat this disorder are solely symptomatic, making the need for new molecular entities acting on the causes of the disease extremely urgent. One of the potential solutions is to use compounds that are already in the market. The structures have known pharmacokinetics, pharmacodynamics, toxicity profiles, and patient data available in several countries. Several drugs have been used successfully to treat diseases different from their original purposes, such as autoimmunity and peripheral inflammation. Herein, we divulge the repurposing of drugs in the area of neurodegenerative diseases, focusing on the therapeutic potential of antineoplastics to treat dementia due to AD and dementia. We briefly touch upon the shared pathological mechanism between AD and cancer and drug repurposing strategies, with a focus on artificial intelligence. Next, we bring out the current status of research on the development of drugs, provide supporting evidence from retrospective, clinical, and preclinical studies on antineoplastic use, and bring in new areas, such as repurposing drugs for the prion-like spreading of pathologies in treating AD.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MEDICINAL RESEARCH REVIEWS
ISSN
0198-6325
e-ISSN
1098-1128
Volume of the periodical
44
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
34
Pages from-to
2078-2111
UT code for WoS article
001190758000001
EID of the result in the Scopus database
2-s2.0-85189562523