The influence of platinum-based drugs on the amount of metallothionein

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F05%3A00007603" target="_blank" >RIV/62156489:43210/05:00007603 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The influence of platinum-based drugs on the amount of metallothionein

Original language description

Neoplastic diseases represent one of the most prevalent human disorders. Many of those are generally treated by platinum-complexes. Effectiveness of such treatment depends on the therapeutic concentration of the drug, commonly influenced by binding to proteins (e.g. metallothionein). Metallothionein (MT) is a well-known molecular protein maintaining metal ion homeostasis. The aim of this work was to study the interaction of MT with Pt compounds. The proper interaction was observed in our experiments invitro by means of electrochemical techniques using the oxidation-reduction and/or catalytic signals (metallothionein-SH groups reduction, Brdicka reaction, and H-peak). Our suggested technique was used for blood serum analysis from the patients treated with standard platinum compounds. The MT amount was increased more than 10 times in these patients´serum in comparison with non-treated patients. The results thus show that the MT amount has a significant negative influence on the therapy

Czech name

Vliv platinových léčiv na obsah metalothioneinu

Czech description

Neoplastic diseases represent one of the most prevalent human disorders. Many of those are generally treated by platinum-complexes. Effectiveness of such treatment depends on the therapeutic concentration of the drug, commonly influenced by binding to proteins (e.g. metallothionein). Metallothionein (MT) is a well-known molecular protein maintaining metal ion homeostasis. The aim of this work was to study the interaction of MT with Pt compounds. The proper interaction was observed in our experiments invitro by means of electrochemical techniques using the oxidation-reduction and/or catalytic signals (metallothionein-SH groups reduction, Brdicka reaction, and H-peak). Our suggested technique was used for blood serum analysis from the patients treated with standard platinum compounds. The MT amount was increased more than 10 times in these patients´serum in comparison with non-treated patients. The results thus show that the MT amount has a significant negative influence on the therapy

Type

D - Article in proceedings

CEP classification

CG - Electrochemistry

OECD FORD branch

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Project

<a href="/en/project/GP525%2F04%2FP132" target="_blank" >GP525/04/P132: Study of protection mechanisms for stress-induced by heavy metals</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Eurotox 2005; 42nd Congress of European Societes of Toxicology

ISBN

0378-4274

ISSN

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e-ISSN

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Number of pages

2

Pages from-to

"S66"-"S67"

Publisher name

Elsevier

Place of publication

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Event location

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Event date

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Type of event by nationality

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UT code for WoS article

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