Study of Binding of Platinum Cytostatic to DNA Structure: Therapeutic Concentration of Platinum Cytostatic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F05%3A00086666" target="_blank" >RIV/62156489:43210/05:00086666 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Study of Binding of Platinum Cytostatic to DNA Structure: Therapeutic Concentration of Platinum Cytostatic

Original language description

Neoplastic diseases represent one of the most prevalent human disorders. Many of those are generally treated by platinum-complexes[1]. Effectiveness of such treatment depends on the therapeutic concentration of the drug, commonly influenced by binding toproteins (e.g. metallothionein). The metallothionein (MT) family is a class of low molecular weight, intracellular and cysteine-rich proteins presenting high affinity for metal ions[2]. Metallothionein is a well-known heavy metal binding protein maintaining metal ion homeostasis[3]. The aim of this work was to study the interaction of MT with Pt compounds. The proper interaction was observed in vitro by means of electrochemical techniques using the oxidation-reduction and/or catalytic signals (metallothionein-SH groups reduction, Brdicka reaction, and H-peak)[4]. Our suggested technique was used for analysis of blood serum of the patients treated with standard platinum compounds. The MT amount increased in this patients' serum more tha

Czech name

Studium vazby cytostatik na bázi platiny do DNA struktury: Terapeutická koncentrace cytostatik na bázi platiny

Czech description

Neoplastic diseases represent one of the most prevalent human disorders. Many of those are generally treated by platinum-complexes[1]. Effectiveness of such treatment depends on the therapeutic concentration of the drug, commonly influenced by binding toproteins (e.g. metallothionein). The metallothionein (MT) family is a class of low molecular weight, intracellular and cysteine-rich proteins presenting high affinity for metal ions[2]. Metallothionein is a well-known heavy metal binding protein maintaining metal ion homeostasis[3]. The aim of this work was to study the interaction of MT with Pt compounds. The proper interaction was observed in vitro by means of electrochemical techniques using the oxidation-reduction and/or catalytic signals (metallothionein-SH groups reduction, Brdicka reaction, and H-peak)[4]. Our suggested technique was used for analysis of blood serum of the patients treated with standard platinum compounds. The MT amount increased in this patients' serum more tha

Type

D - Article in proceedings

CEP classification

CE - Biochemistry

OECD FORD branch

—

Project

<a href="/en/project/GP525%2F04%2FP132" target="_blank" >GP525/04/P132: Study of protection mechanisms for stress-induced by heavy metals</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

45th Annual Meeting of The American Society for Cell Biology

ISBN

1059-1524

ISSN

—

e-ISSN

—

Number of pages

1

Pages from-to

"382a"-382a"

Publisher name

The American Society for Cell Biology

Place of publication

San Francisco, USA

Event location

—

Event date

—

Type of event by nationality

—

UT code for WoS article

—