Induction of Synthesis of Metallothionein by Platinum Based Drugs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F05%3A00086863" target="_blank" >RIV/62156489:43210/05:00086863 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Induction of Synthesis of Metallothionein by Platinum Based Drugs

Original language description

Neoplastic diseases represent one of the most prevalent human disorders. Many of those are generally treated by platinum-complexes. Effectiveness of such treatment depends on the therapeutic concentration of the drug commonly influenced by binding to proteins (e.g. metallothionein). The metallothionein (MT) family is class of low molecular, intracellular and cysteine-rich proteins presenting high affinity for metal ions. Metallothionein is a well-known heavy metal binding protein maintaining metal ion homeostasis. In human organisms MTs are usually abundant at low concentrations levels. Their marked expression is caused by many exogenous and endogenous factors such as UV radiation, heavy metals, xenobiotic species, reactive oxygen species etc. The aimof this work was to study the interaction of MT with Pt compounds. The proper interaction was observed in vitro by means of electrochemical techniques using the oxidation-reduction and/or catalytic signals (Brdicka reaction, and peak H).

Czech name

Indukce syntézy Metalotioneinu pomocí léků založených na platině

Czech description

Neoplastic diseases represent one of the most prevalent human disorders. Many of those are generally treated by platinum-complexes. Effectiveness of such treatment depends on the therapeutic concentration of the drug commonly influenced by binding to proteins (e.g. metallothionein). The metallothionein (MT) family is class of low molecular, intracellular and cysteine-rich proteins presenting high affinity for metal ions. Metallothionein is a well-known heavy metal binding protein maintaining metal ion homeostasis. In human organisms MTs are usually abundant at low concentrations levels. Their marked expression is caused by many exogenous and endogenous factors such as UV radiation, heavy metals, xenobiotic species, reactive oxygen species etc. The aimof this work was to study the interaction of MT with Pt compounds. The proper interaction was observed in vitro by means of electrochemical techniques using the oxidation-reduction and/or catalytic signals (Brdicka reaction, and peak H).

Type

D - Article in proceedings

CEP classification

CG - Electrochemistry

OECD FORD branch

—

Project

<a href="/en/project/GP525%2F04%2FP132" target="_blank" >GP525/04/P132: Study of protection mechanisms for stress-induced by heavy metals</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

45th Annual Meeting of The American Society for Cell Biology

ISBN

1059-1524

ISSN

—

e-ISSN

—

Number of pages

1

Pages from-to

"382a"-382a"

Publisher name

The American Society for Cell Biology

Place of publication

San Francisco, USA

Event location

—

Event date

—

Type of event by nationality

—

UT code for WoS article

—