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Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F10%3A00184955" target="_blank" >RIV/62156489:43210/10:00184955 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines

  • Original language description

    Background: Metallothioneins (MTs) are heavy-metal binding cysteine-rich proteins. MTs are thought to play a role in tumour disease. They can be used for studying of course, prognosis and metastating of a tumour. The enhanced MTs expression leads to theformation of cytostatics resistance in tumour cells. One the current accepted opinion is that these mechanisms are closely connected to ability of MT to bind heavy metal ions and form aggregates. The aim of this work was to study the changes in aggregation of MT under various concentrations of zinc and different redox conditions in human prostatic cell lines. Material and Methods: Reduced apo-MT was oxidized with 0.75 and 3.5 % H2O2, 0.5 and 1 mMK2Cr2O7, and 0.5 and 1 mM KMnO4 for 2 hours at 37C. To thereduced and oxidized apo-MT ZnCl2 was added. Reaction was measured spectrometrically for 1 hour at 37 C. MT oxidation and interaction with zinc was evaluated by measuring of spectra within the range from 200 to 300 nm. Human cancer prost

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CB - Analytical chemistry, separation

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2010

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European Journal of Cancer

  • ISSN

    0959-8049

  • e-ISSN

  • Volume of the periodical

    8

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    1

  • Pages from-to

    49

  • UT code for WoS article

  • EID of the result in the Scopus database