Porcine insulin receptor substrate 4 (IRS4) gene: cloning, polymorphism and association study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F11%3A00165366" target="_blank" >RIV/62156489:43210/11:00165366 - isvavai.cz</a>

Alternative codes found

RIV/67985904:_____/10:00353420

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Porcine insulin receptor substrate 4 (IRS4) gene: cloning, polymorphism and association study

Original language description

Using PCR and inverse PCR techniques we obtained a 4,498 bp nucleotide sequence FN424076 encompassing the complete coding sequence of the porcine insulin receptor substrate 4 (IRS4) gene and its proximal promoter. The 1,269 amino acid porcine protein deduced from the nucleotide sequence shares 92% identity with the human IRS4 and possesses the same domains and the same number of tyrosine phosphorylation motifs as the human protein. We detected substitution FN424076:g.96CG in the promoter region that segregates in Meishan and a synonymous substitution FN424076:g.1829TC in the coding sequence with allele C present only in Meishan. Linkage mapping placed the IRS4 gene at position 82 cM on the current USDA--USMARC linkage map of porcine chromosome X. Association analyses were performed on 555 animals of 12th--15th generation of the Meishan 9 Large White cross and showed that both SNPs were highly significantly associated with backfat depth (P = 0.0005) and that the SNP FN424076:g1829TC

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Biology Reports

ISSN

0301-4851

e-ISSN

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Volume of the periodical

38

Issue of the periodical within the volume

4

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

7

Pages from-to

2611-2617

UT code for WoS article

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EID of the result in the Scopus database

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