Capillary electromigration based techniques in diagnostics of prion protein caused diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F12%3A00193598" target="_blank" >RIV/62156489:43210/12:00193598 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26620/12:PU126731

Result on the web

<a href="http://dx.doi.org/10.1002/elps.201200208" target="_blank" >http://dx.doi.org/10.1002/elps.201200208</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/elps.201200208" target="_blank" >10.1002/elps.201200208</a>

Result language

angličtina

Original language name

Capillary electromigration based techniques in diagnostics of prion protein caused diseases

Original language description

Transmissible spongiform encephalopathies are a group of fatal neurodegenerative diseases with long incubation time. This group includes Creutzfeld-Jakob disease, kuru, scrapie, chronic wasting disease, and bovine spongiform encephalopathy. Sensitive andspecific detection of abnormal prion protein as "a source agent" of the above-mentioned diseases in blood could provide a diagnostic test or a screening assay for animal and human prion protein diseases diagnostics. Therefore, diagnostic tests for prionprotein diseases represent unique challenge requiring development of novel assays exploiting properties of prion protein complex. Presently, diagnostic methods such as protein misfolding cyclic amplification, conformation-dependent immunoassay, dissociation-enhanced lanthanide fluorescent immunoassay, fluorescence correlation spectroscopy, and/or flow microbead immunoassay are used for abnormal prion protein (PrPSc) detection. On the other hand, using of CE for PrPSc detection in body f

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Electrophoresis

ISSN

0173-0835

e-ISSN

—

Volume of the periodical

33

Issue of the periodical within the volume

24

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

3644-3652

UT code for WoS article

312548900007

EID of the result in the Scopus database

—