Femtogram electrochemical sensing of prion proteins using quantum dots

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F13%3A00213512" target="_blank" >RIV/62156489:43210/13:00213512 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/13:00072405 RIV/00216305:26620/13:PU105964
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Femtogram electrochemical sensing of prion proteins using quantum dots
Original language description
The prion protein (PrP) is involved in neurodegeneration via its conversion from the normal cellular form, PrPC, to the infectious form, PrPSc, which is the causative agent of the transmissible spongiform encephalopathies (TSEs) including Creutzfeldt-Jakob disease (CJD). In spite of great effort in this field, diagnostics of prion protein caused diseases represents a sort of challenge. In this study, we aimed our attention on studying of prion protein interaction with CdTe quantum dots (QDs) by voltammetry as a new and extremely sensitive tool for sensing of these proteins. Primarily, we characterized fluorescent and electrochemical properties of QDs. Further, electrochemical study of their interactions was carried out to find the most suitable conditions for sensitive detection of prion proteins. Detection limit (3 S/N) was estimated as 1 fg in 5 ul. This makes labeling of proteins with QDs of great importance due to easy applicability and possibility to use in miniaturized devices, w
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
O - Projekt operacniho programu

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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