G-Quadruplexes as sensing probes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F13%3A00213412" target="_blank" >RIV/62156489:43210/13:00213412 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/13:PU126700
Result on the web
<a href="http://dx.doi.org/10.3390/molecules181214760" target="_blank" >http://dx.doi.org/10.3390/molecules181214760</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules181214760" target="_blank" >10.3390/molecules181214760</a>
Alternative languages
Result language
angličtina
Original language name
G-Quadruplexes as sensing probes
Original language description
Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. G-quadruplexes act as ligands for metal ions and aptamers for various molecules. Interestingly, the G-quadruplexes form a complex with anionic porphyrin hemin and exhibit peroxidase-like activity. This review focuses on overview of sensing techniques based on G-quadruplex complexes with anionic porphyrins for detection of various analytes, including metal ions such as K+, Ca2+, Ag+, Hg2+, Cu2+, Pb2+, Sr2+, organic molecules, nucleic acids, and proteins. Principles of G-quadruplex-based detection methods involve DNA conformational change caused by the presence of analyte which leads to a decrease or an increase in peroxidase activity, fluorescence, or electrochemical signal of the used probe. The advantages of various detection techniques are also discussed.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecules
ISSN
1420-3049
e-ISSN
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Volume of the periodical
18
Issue of the periodical within the volume
12
Country of publishing house
CH - SWITZERLAND
Number of pages
20
Pages from-to
14760-14779
UT code for WoS article
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EID of the result in the Scopus database
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