Electrochemical and spectrometric study of GFP-AZT interaction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F14%3A00225096" target="_blank" >RIV/62156489:43210/14:00225096 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26620/14:PU125827

Result on the web

<a href="http://www.researchgate.net/publication/261758775_Electrochemical_and_Spectrometric_Study_of_GFP-AZT_Interaction" target="_blank" >http://www.researchgate.net/publication/261758775_Electrochemical_and_Spectrometric_Study_of_GFP-AZT_Interaction</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Electrochemical and spectrometric study of GFP-AZT interaction

Original language description

In the last 18 years the highly active antiretroviral therapy (HAART) has been used for the treatment of HIV and consists of the combination of various drugs. The introduction of this type of treatment caused a significant extension of lives of patientsand a reduction of side effects. However, the complete recovery of patients with HIV is still impossible. Azidothymidine (AZT) was the first drug used for the treatment of HIV and it is used in a combination with other drugs in HAART. Although the mechanism of effect of this drug is known, the mechanisms of side effects are still not sufficiently clarified. The way how to orient even in these reactions is the use of markers that allow in vivo monitoring of biological processes associated with the drug.As a fluorescent label the green fluorescent protein (GFP) can be used. In this study, we evaluated the link between AZT and GFP by electrochemical methods and also the change of the properties of GFP fluorescence after the binding/interc

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CG - Electrochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Electrochemical Science

ISSN

1452-3981

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

7

Country of publishing house

RS - THE REPUBLIC OF SERBIA

Number of pages

12

Pages from-to

3419-3430

UT code for WoS article

336899000007

EID of the result in the Scopus database

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