Extension of the microsatellite panel for diversity studies in the equine Ly49 genes region
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F15%3A43906605" target="_blank" >RIV/62156489:43210/15:43906605 - isvavai.cz</a>
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2015/mnet_2015_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2015/mnet_2015_full.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Extension of the microsatellite panel for diversity studies in the equine Ly49 genes region
Original language description
The genetic variability and different expression of genes for receptors underlies functional variability of individual natural killer cells (NK). Like in the mouse model, the Ly49 receptors on the horse NK cells are believed to bind MHC class I moleculesof target cells. Six Ly49genes constitute a gene family located on the horse chromosome 6, between 38 200 Kbp -38 520 Kbp. Immune-response genes represent a functionally important region of the vertebrate genome subject to selection pressure. NK cells are involved in the antigen recognition process through their highly variable receptors. Our work may contribute to better estimating the genetic diversity of this functionally important region. In this work, we identified and genotyped three new polymorphic microsatellite markers that expand the original panel of microsatellite sand are located in the Ly49region.This methodology will be used for assessment genetic diversity and association analyses with selected diseases of horses.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
MendelNet 2015: Proceedings of International PhD Students Conference
ISBN
978-80-7509-363-9
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
462-465
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 11, 2015
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000366466100087