NKR genes region and their genetic diversity in horses
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F14%3A00229347" target="_blank" >RIV/62156489:43210/14:00229347 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
NKR genes region and their genetic diversity in horses
Original language description
The genes of the immune response represent a functionally important region of vertebrate genome with demonstrated intense effect of selection. Natural killer cells (NK) are related to antigen recognition process through their highly variable receptors. The genetic variability and different expression of genes for receptors underlies functional variability of individual NK cells. As like in mouse model, the Ly49 receptors on horse NK cells are believed to bind to MHC class I molecules of target cells. The six Ly49 genes form a gene family located on horse chromosome 6 between 38 200 Kbp -- 38 500 Kbp. In this work were identified and genotyped nine microsatellites located in NK cell receptors (NKR) region, which includes genes Ly49. Using this methodological work may contribute to the estimate of its genetic diversity in this functionally important region. This methodology will be used for the association analysis of selected diseases in horses.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
MendelNet 2014 - Proceedings of International PhD Students Conference
ISBN
978-80-7509-174-1
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
490-493
Publisher name
Mendel University in Brno
Place of publication
Brno, Czech Republic
Event location
Brno, Czech Republic
Event date
Nov 19, 2014
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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