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Complex variation in the KLRA (LY49) immunity‐related genomic region in horses

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F20%3AN0000079" target="_blank" >RIV/00027162:_____/20:N0000079 - isvavai.cz</a>

  • Alternative codes found

    RIV/62157124:16170/20:43878571 RIV/62157124:16810/20:43878571

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.13939" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.13939</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/tan.13939" target="_blank" >10.1111/tan.13939</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Complex variation in the KLRA (LY49) immunity‐related genomic region in horses

  • Original language description

    "Natural killer (NK) cells play important roles in innate and adaptive immunity, as well as in the reproduction of placental mammals. Ly49 (KLRA) molecules represent a lectin‐like type of NK cell receptor encoded within a complex genomic region, the NK cell complex. In rodents and horses, an expansion of the genes encoding Ly49 receptors leading to the formation of a gene family was observed. High sequence similarities and frequent high polymorphism of multiple family members represent an obstacle both for their individual identification and for annotation in the reference genomes of their respective species. Here, we focused on resolving complex variation of the KLRA gene family observed in domestic and Przewalski's horses. The KLRA (LY49) genomic region contains six genes (KLRA2‐KLRA7) and one putative pseudogene, KLRA1. Two types of polymorphism were observed in the horses analyzed. Copy number variation between haplotypes was documented for the gene KLRA7 by polymerase chain reaction. As expected, the major source of variation of all KLRA genes, including KLRA7, is because of single nucleotide polymorphisms, many of them being nonsynonymous substitutions. Extensive allelic variability of the expanded KLRA (LY49) genes was observed. For four out of the six functional KLRA, high numbers of novel allelic amino acid sequence variants were identified in the genes studied, suggesting that this variation might be of functional importance, especially in the context of high polymorphism of their presumed ligands encoded by major histocompatibility complex class I genes. In fact, polymorphic amino acid sites were mostly found in the ligand‐binding C‐type lectin‐like domain of the putative receptor molecule. "

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    HLA

  • ISSN

    2059-2302

  • e-ISSN

    2059-2310

  • Volume of the periodical

    96

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    257-267

  • UT code for WoS article

    000545706200001

  • EID of the result in the Scopus database

    2-s2.0-85087303165