ELISA-like Analysis of Cisplatinated DNA Using Magnetic Separation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F15%3A43907734" target="_blank" >RIV/62156489:43210/15:43907734 - isvavai.cz</a>
Result on the web
<a href="http://www.intechopen.com/journals/nanobiomedicine/elisa-like-analysis-of-cisplatinated-dna-using-magnetic-separation" target="_blank" >http://www.intechopen.com/journals/nanobiomedicine/elisa-like-analysis-of-cisplatinated-dna-using-magnetic-separation</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5772/61699" target="_blank" >10.5772/61699</a>
Alternative languages
Result language
angličtina
Original language name
ELISA-like Analysis of Cisplatinated DNA Using Magnetic Separation
Original language description
Cisplatin belongs to the most widely used cytostatic drugs. The determination of the presence of the DNA-cisplatin adducts may not only signal the guanine-rich regions but also monitor the interaction reaction between DNA and the drug in terms of speed of interaction.In this work, the combined advantages of magnetic particles-based isolation/purification with fluorescent properties of quantum dots (QDs) and antibodies targeted on specific recognition of DNA-cisplatin adducts are demonstrated. The formation of a complex between magnetic particles with surface modified by anti-dsDNA antibody, cisplatin-modified DNA and QDs labelled anti-cisplatin-modified DNA antibody was suggested and optimized.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP102%2F11%2F1068" target="_blank" >GAP102/11/1068: Nano-Electro-Bio-Tools for Biochemical and Molecularly-Biological Studies of Eukaryotic Cells (NanoBioTECell)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanobiomedicine
ISSN
1849-5435
e-ISSN
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Volume of the periodical
2
Issue of the periodical within the volume
10
Country of publishing house
HR - CROATIA
Number of pages
8
Pages from-to
"nestrankovano"
UT code for WoS article
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EID of the result in the Scopus database
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