Antioxidant status of rats' blood and liver affected by sodium selenite and selenium nanoparticles

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F18%3A43913711" target="_blank" >RIV/62156489:43210/18:43913711 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26620/18:PU128261

Result on the web

<a href="https://doi.org/10.7717/peerj.4862" target="_blank" >https://doi.org/10.7717/peerj.4862</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7717/peerj.4862" target="_blank" >10.7717/peerj.4862</a>

Result language

angličtina

Original language name

Antioxidant status of rats' blood and liver affected by sodium selenite and selenium nanoparticles

Original language description

Background: Selenium is an essential element; however, at higher doses, it can be toxic. Therefore, alternative nanotechnological solutions are required to overcome toxicological issues, rather than conventional alternatives. Nanoparticles show new and promising properties that may be able to suppress toxicity while maintaining the positive effects of selenium on an organism. The aim of the experiment was to determine the influence of sodium selenite and selenium nanoparticles (SeNPs) on the antioxidant status of rats. Methods: The males of the outbreed rat strain Wistar albino were selected as a model organism. Animals were fed different forms of selenium. The control group was given a mixture without selenium addition, whereas other groups were fed a mixture containing sodium selenite, Se-49, and Se-100 SeNPs respectively. The duration of the trial was 30 days. Results: Analysis of blood and liver was performed where the concentration of reduced (GSH) and oxidised (GSSG) glutathione, and total selenium content were measured. In the liver, a significant reduction in GSSG was found for all experiment groups. Blood samples showed a significant reduction in GSH and an increase in GSSG. Discussion: These results show that SeNPs may be an alternative to dietary selenium for animal organisms.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PeerJ

ISSN

2167-8359

e-ISSN

—

Volume of the periodical

6

Issue of the periodical within the volume

28 May

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

"Nestrankovano"

UT code for WoS article

000434233100008

EID of the result in the Scopus database

2-s2.0-85047624698